Design and Evaluation of Jingzhiguanxin Monolithic Osmotic Pump Tablet
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چکیده
منابع مشابه
Development and Evaluation of Monolithic Osmotic Tablet of Ketoprofen: Using Solid Dispersion Technique
Objective: The aim of the present study was to develop and evaluate the monolithic osmotic tablet (MOT) composed of the solid dispersion of ketoprofen (KETO), a poorly water-soluble drug. Solid dispersion technique is generally used for immediate release, as this maximizes the amount of drug absorbed. Sustained release may be obtained by combining solid dispersion technique with MOT so as to in...
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The aim of this study was to evaluate the monolithic osmotic tablet system (MOTS) containing a solid dispersion with the practically water-insoluble drug nifedipine in vitro and in vivo. In the drug release study in vitro, the release profiles of this system had almost zero-order kinetics. The influences of tablet formulation variables, sizes of the delivery orifice, membrane variables, and val...
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PURPOSE Find a novel delivery system for oral administration of drugs that have absorption window in the upper part of gastrointestinal (GI) track. METHODS Dipyridamole was chosen as the model drug. A novel system, which combined the osmotic pump controlled release system and the floating system, was designed; matrix tablets (MT) were prepared for compares. The effects of pH, temperature and ...
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The present work investigates the feasibility of the design of an enteric coated microporous osmotic pump tablet (ECMOPT) to prolong the drug release of an antipsychotic drug, quetiapine fumarate (QTF). The ECMOPT consisted of an osmotic core coated with a microporous membrane (MPM) made up of cellulose acetate and PEG 4000 as in situ micropore former. The effect of formulation variables such a...
متن کاملdevelopment and optimization of buspirone oral osmotic pump tablet
the aim of the current study was to design a porous osmotic pump–based drug delivery system for controlling the release of buspirone from the delivery system. the osmotic pump was successfully developed using symmetric membrane coating. the core of the tablets was prepared by direct compression technique and coated using dip-coating technique. drug release from the osmotic system was studied us...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 2006
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.54.465